nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg searchdiv qikanlogo popupnotification paper
2025 01 v.34 1-12
栀子花中化学成分及药理作用研究进展
基金项目(Foundation): 江西省自然科学基金(20232BAB206160)
邮箱(Email):
DOI:
中文作者单位:

宜春学院化学与生物工程学院;井冈山大学医学部;

摘要(Abstract):

通过综述栀子花中化学成分和药理作用研究进展,以期为栀子花的研究提供参考.通过查阅国内外相关文献和书籍,总结归纳栀子花的化学成分及药理作用研究.结果表明,栀子花主要含有环烯醚萜类、黄酮类、三萜类等化学成分,具有保护神经、保护肝脏、降糖、抗类风湿关节炎等作用,随着药理作用和相关靶点及通路的深入研究,栀子花的药理作用机制将不断被阐明.现将栀子花化学成分及药理作用的研究进展进行综述,以期为栀子花的进一步研究提供参考.

关键词(KeyWords): 栀子花;化学成分;药理作用;环烯醚萜类
参考文献

[1]陈雅林.栀子属资源概况及栀子本草学研究[D].北京:协和医学院,2018.

[2]李明利,赵佳堔,金艳,等.经典名方中栀子的本草考证[J].中国现代中药,2020, 22(8):1287-1302.

[3]李兆星,申洁,毕武,等.中国栀子属植物资源及利用研究进展[J].中药材,2017, 40(2):498-503.

[4]国家中医药管理局《中华本草》编委会.《中华本草》[M].上海:科学技术出版社,1999.

[5]张家建,寿旦,章建民,等.栀子花药用价值分析研究[J].浙江中医杂志,2008, 7:424-425.

[6]王燕兰.两种保健食品原料来源中药的化学成分研究[D].杭州:浙江大学,2018.

[7]严欢,左月明,袁恩,等.基于UHPLC-Q-TOF-MS技术分析栀子花的化学成分[J].中药材,2018, 41(6):1359-1364.

[8] ZHANG H, FENG N, XU Y T, et al. Chemical constituents from the flowers of wild Gardenia jasminoides J. Ellis[J]. Chemistry&Biodiversity, 2017, 14(5):e1600437.

[9] SONG J L, WANG R, SHI Y P, et al. Iridoids from the flowers of Gardenia jasminoides Ellis and their chemotaxonomic significance[J]. Biochemical Systematics and Ecology, 2014, 56:267-270.

[10] RAGASA C Y, PIMENTA L E N, RIDEOUT J A. Iridoids from Gardenia jasminoides[J]. Natural Product Research, 2007,21(12):1078-1084.

[11] WATANABE N, NAKAJIMA R, WATANABE S, et al. Linalyl and bornyl disaccharide glycosides from Gardenia jasminoides flowers[J]. Phytochemistry, 1994, 37(2):457-459.

[12]宋家玲,杨永建,戚欢阳,等.栀子花化学成分研究[J].中药材,2013, 36(5):752-755.

[13]梁惠玲,郑惠兰,陈泗英.黄栀子花中的色素[J].云南植物研究,1991(1):95-96.

[14]杨前东.栀子花的化学成分及其α-糖苷酶抑制活性研究[D].宜春:宜春学院,2021.

[15]冯宁,卢成淑,南国,等.栀子花的化学成分研究[J].中草药,2016, 47(2):200-203.

[16] QIN G, XU R. Studies on the chemical constituents of Gardenia jasminoides[J]. Planta Medica, 1991, 57(S2):A75.

[17]邓蒙生.京尼平苷调节神经元非折叠蛋白反应影响APP降解的分子机制研究[D].重庆:重庆理工大学,2017.

[18]张志华.京尼平苷对APP/PS1小鼠行为学损伤和病理变化的保护作用及分子机制—抑制mTOR信号通路增强自噬的研究[D].太原:山西医科大学,2019.

[19] ZHAO C, ZHANG H, LI H, et al. Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice[J]. Neuropharmacology, 2017, 116:18-29.

[20] ZHAO C, LV C, LI H, et al. Geniposide protects primary cortical neurons against oligomeric Aβ 1-42-induced neurotoxicity through a mitochondrial pathway[J]. PLoS One, 2016, 11(4):e0152551.

[21] HUANG X F, LI J J, TAO Y G, et al. Geniposide attenuates Aβ 25-35-induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells[J]. RSC advances, 2018, 8(34):18926-18937.

[22]董璐萌.中药栀子对APP/PS1/Tau三转基因阿尔茨海默症小鼠药理活性研究[D].遵义:遵义医学院,2018.

[23]向绍通,徐书雯,肖豪,等.栀子苷通过ERK1/2-Nrf2通路发挥对Aβ 25-35诱导的阿尔兹海默病大鼠模型的神经保护作用[J].华中科技大学学报(医学版),2018, 47(1):27-32.

[24]陈紫微,张前,何芳,等.栀子花精油芳香疗法对阿尔兹海默症双转基因模型小鼠运动及焦虑的影响[J].北京中医药大学学报,2020, 43(7):569-574.

[25]苏春贺.京尼平苷对帕金森病模型神经保护作用的研究[D].郑州:郑州大学,2018.

[26] CHEN Y M, ZHANG Y, LI L, et al. Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson′s disease[J]. European Journal of Pharmacology, 2015, 768:21-27.

[27]朱宁,马晓珊,陈春丽,等.京尼平苷通过AMPK/mTOR通路抑制帕金森模型化应激及细胞凋亡的机制研究[J].河北医科大学学报,2021, 42(9):1008-1015.

[28]符晶,孟开顺.京尼平苷对帕金森病细胞模型的线粒体保护作用[J].中国临床药理学杂志,2019, 35(18):2132-2134.

[29]骆晓峰,李瑶,胡江,等.栀子苷对实验性帕金森病大鼠睡眠障碍的调节作用及其机制[J].吉林大学学报(医学版),2020, 46(6):1177-1181.

[30] ZHENG M, LI K, CHEN T, et al. Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice[J]. Brain Research Bulletin, 2021, 170:65-73.

[31] WANG M, YANG L, CHEN Z, et al. Geniposide ameliorates chronic unpredictable mild stress induced depression-like behavior through inhibition of ceramide-PP2A signaling via the PI3K/Akt/GSK3β axis[J]. Psychopharmacology, 2021, 238(10):2789-2800.

[32] ZOU T, SUGIMOTO K, ZHANG J, et al. Geniposide alleviates oxidative stress of mice with depression-like behaviors by upregulating six3os1[J]. Frontiers in Cell and Developmental Biology, 2020, 8:553728.

[33] ZOU T, ZHANG J, LIU Y, et al. Antidepressant-like effect of Geniposide in mice exposed to a chronic mild stress involves the microRNA-298-5p-mediated Nox1[J]. Frontiers in Molecular Neuroscience, 2021, 13:131.

[34] CAI L, LI R, TANG W, et al. Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis[J]. European Neuropsychopharmacology, 2015, 25(8):1332-1341.

[35]崔立勋.肠道菌群介导的栀子苷抗抑郁作用机制研究[D].上海:中国人民解放军海军军医大学,2022.

[36]刘春燕. AMPK在京尼平苷拮抗高糖诱导的胰腺β细胞损伤中的作用机制研究[D].重庆:重庆理工大学,2017.

[37]蒋孝清,申甚莉,李维钊,等.京尼平苷调节胰腺β细胞GLUT2糖基化的分子机制[J].中国中药杂志,2021, 46(14):3643-3649.

[38]申甚莉.京尼平苷调节胰腺β细胞GLUT2内吞的分子机制研究[D].重庆:重庆理工大学,2019.

[39]崔华清. Txnip与京尼平苷调节胰腺β细胞内质网应激的相关性研究[D].重庆:重庆理工大学,2018.

[40]蒲梦如. Txnip与京尼平苷改善脂肪细胞胰岛素抵抗的相关性研究[D].重庆:重庆理工大学,2019.

[41] JIANG H, MA Y, YAN J, et al. Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62/NF-κB/GLUT-4[J]. Molecular Medicine Reports, 2017, 16(5):7237-7244.

[42]潘春,唐定乾,胡婧晔,等.栀子苷对2型糖尿病大鼠胰岛细胞的保护作用[J].糖尿病新界,2018, 21(8):27-28.

[43]戴标,施丽丹,谢鸣部,等.栀子苷改善糖尿病肾病小鼠肾功能的作用[J].解剖学研究,2023, 45(1):40-45.

[44]代圣洁,张巧云,蓝青,等. PK2/PKR1信号参与京尼平苷对小鼠糖尿病肾病的保护作用[J].中国中药杂志,2022,47(6):1611-1617.

[45] DUSABIMANA T, PARK E J, JE J, et al. Geniposide improves diabetic nephropathy by enhancing ULK1-mediated autophagy and reducing oxidative stress through AMPK activation[J]. International Journal of Molecular Sciences, 2021,22(4):1651.

[46]朱亚文.栀子苷对1型糖尿病心肌损伤的保护作用和机制研究[D].上海:上海海洋大学,2021.

[47]张伟萍,江建军,陈晓锋,等.栀子苷通过抑制VPO1/ERK1/2信号通路减轻糖尿病心肌病大鼠的心肌细胞凋亡[J].中国临床药理学与治疗学,2021, 26(2):129-136.

[48]邵青森,黄豪,吴春兴,等.穿龙薯蓣的化学成分及药理作用研究进展[J].宜春学院学报,2022, 44(12):20-25.

[49]王荣慧.栀子苷抑制鞘氨醇激酶1过度转位恢复佐剂性关节炎小鼠巨噬细胞极化平衡[D].合肥:安徽中医药大学,2022.

[50]李锋.栀子苷介导SphK1/S1P/S1PR1信号通路调控滑膜炎性微环境中血管内皮细胞对成纤维样滑膜细胞的影响[D].合肥:安徽中医药大学,2019.

[51] WANG Y, DAI L, WU H, et al. Novel anti-inflammatory target of geniposide:inhibiting Itg β1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts[J]. International Immunopharmacology, 2018, 65:284-294.

[52]邓然.栀子苷调控S1P-S1PR1及其下游RhoA-F-actin-NF-кB信号通路干预成纤维滑膜细胞对血管内皮细胞生物学功能影响[D].合肥:安徽中医药大学,2019.

[53]孙明慧.缺氧抑制PHDs/pVHL/HIF-α信号转导促进类风湿关节炎成纤维样滑膜细胞增殖及栀子苷作用机制研究[D].合肥:安徽中医药大学,2021.

[54]章东明.京尼平苷对佐剂性关节炎大鼠的抗炎作用分析[J].基因组学与应用生物学,2020, 39(8):3797-3802.

[55]邓然. JNK介导BNIP3过度磷酸化对缺氧下类风湿关节炎成纤维样滑膜细胞线粒体自噬/凋亡调节机制及栀子苷的干预[D].合肥:安徽中医药大学,2022.

[56]戴学静.栀子苷调控S1PR1/2/3偶联Gαi/Gαs转换对类风湿关节炎成纤维样滑膜细胞功能的影响[D].合肥:安徽中医药大学,2020.

[57] BU Y, WU H, DENG R, et al. The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN[J]. Inflammopharmacology, 2022, 30(3):1047-1062.

[58] GAN P, SUN M, WU H, et al. A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes:geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synovium[J]. Inflammation Research, 2022, 71(10-11):1375-1388.

[59]徐星科,边阳萍,赵婉均,等.京尼平苷通过调节Perilipin-2表达对肝细胞脂滴形成的影响[J].中成药,2022, 44(6):1798-1803.

[60] YANG L, BI L, JIN L, et al. Geniposide ameliorates liver fibrosis through reducing oxidative stress and inflammatory respose,inhibiting apoptosis and modulating overall metabolism[J]. Frontiers in Pharmacology, 2021, 12:772635.

[61] SHEN B, FENG H, CHENG J, et al. Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways[J]. Journal of Cellular and Molecular Medicine, 2020, 24(9):5097-5108.

[62] WEN M, LIU Y, CHEN R, et al. Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis[J]. Phytotherapy Research, 2021, 35(7):3799-3811.

[63]周林华,陈晓.栀子苷通过TGF-β1/Smad信号通路抑制肝纤维化和肝星状细胞活化[J].生理学报,2022, 74(2):217-224.

[64]佘丹.京尼平苷在大鼠体内的毒代动力学研究[D].广州:广州中医药大学,2015.

[65]王晓慧,张帆,王利军,等.京尼平苷和京尼平的肝毒性比较研究[J].中国临床药理学杂志,2022, 38(1):44-47.

[66]任艳青,田宇柔,李琛,等.京尼平苷及其体内代谢产物京尼平对HepG2细胞毒性的比较及机制研究[J].中国药理学通报,2016, 32(12):1755-1761.

[67]冯筱懿.中药栀子及其成分栀子苷对肾脏毒性及机制初步研究[D].北京:首都医科大学,2016.

[68] CHANG C H, WU J B, YANG J S, et al. The suppressive effects of geniposide and genipin on Helicobacter pylori infections in vitro and in vivo[J]. Journal of Food Science, 2017, 82(12):3021-3028.

[69]张耘实.栀子苷对甲型H1N1流感病毒抑制效应的实验研究[D].南京:南京医科大学,2016.

[70]谭慧敏,周亮,邹慧禅.栀子苷介导GLP-1R/Akt信号通路改善大鼠脑缺血再灌注损伤和神经元凋亡的研究[J].药物评价研究,2022, 45(9):1822-1829.

[71]杭文地,班佳艺,赵志英,等.栀子苷对肺缺血再灌注的保护作用及其与p-Akt和NF-κB表达的关系[J].中国社区医师,2019, 35(4):5-6.

[72]马金安,刘晓明,邓晋锋,等.栀子苷预处理对大鼠心肌缺血再灌注后PI3K/Akt信号通路的研究[J].临床和实验医学杂志,2018, 17(20):2152-2155.

[73] CHEN Z, LIU W, QIN Z, et al. Geniposide exhibits anticancer activity to medulloblastoma cells by downregulating microRNA-373[J]. Journal of Biochemical and Molecular Toxicology, 2020, 34(5):e22471.

[74]时延龙,周鹏,王雪凯,等.栀子苷通过AMPK/SIRT1/NF-κB通路调节乳腺癌细胞增殖、焦亡和侵袭[J].广西医科大学学报,2022, 39(11):1700-1705.

[75]于雅勤,沈加熙,张虹.栀子苷对结直肠癌细胞增殖和凋亡及Akt/MDM2/p53通路的影响[J].浙江中西医结合杂志,2022, 32(1):5-10.

[76]龚丽红,田晓宁,谭继英,等.京尼平苷对宫颈癌Hela细胞增殖与凋亡的影响[J].哈尔滨医科大学学报,2019,53(4):381-384.

[77]汤军华,沈毅弘.栀子苷对支气管哮喘幼年小鼠气道炎性反应的抑制作用[J].中国临床药理学杂志,2019, 35(20):2581-2583.

[78] JIN Z, LI J, PI J, et al. Geniposide alleviates atherosclerosis by regulating macrophage polarization via the FOS/MAPK signaling pathway[J]. Biomedicine&Pharmacotherapy, 2020, 125:110015.

[79] CHIN Y W, CAI X F, AHN K S, et al. Cytotoxic sesquilignans from the roots of Saururus chinensis[J]. Bulletin of the Korean Chemical Society, 2010, 31(7):2088-2090.

基本信息:

DOI:

中图分类号:R284.1;R285

引用信息:

[1]邵青森,黄豪,梁锋等.栀子花中化学成分及药理作用研究进展[J].云南民族大学学报(自然科学版),2025,34(01):1-12.

基金信息:

江西省自然科学基金(20232BAB206160)

检 索 高级检索

引用

GB/T 7714-2015 格式引文
MLA格式引文
APA格式引文