云南民族大学学报(自然科学版)

制备新型蒙药制剂“苏格木勒-3颗粒”，并优选其提取及处方工艺.通过单因素分析方法优化苏格木勒-3挥发油萃取工艺；正交试验优化非挥发油部分提取工艺；采用单因素实验和正交实验优化苏格木勒-3颗粒剂制备工艺，最终确定了挥发油提取工艺条件.大颗粒药材浸泡1 h，提取回流速度为7.5 mL/min，固液比为1∶8 g/mL，提取时间为2 h挥发油提取效果最佳；非挥发油部分提取工艺体积分数为65%的乙醇，固液比为1∶15 g/mL，提取时间为50 min，提取次数为3；筛选出苏格木勒-3颗粒剂处方及制备的最佳工艺，平均得率为95.50%.采用的提取工艺简单，提取效率高，颗粒剂制备工艺可行，为苏格木勒-3的开发提供一定的基础，也对其质量控制提供了科学的实验依据.

The novel Mongolian medicine "Sugemule-3 Granules" was prepared, and its extraction and formulation process was optimized. The volatile oil extraction process of Sugemule-3 was optimized by singlefactor analysis; the extraction process of the non-volatile components was optimized by orthogonal test; the preparation process of Sugemule-3 Granules was optimized by single-factor experiments and orthogonal experiments, ultimately determining the volatile oil extraction conditions. The optimal volatile oil extraction was achieved with coarse medicinal granules soaked for 1 h, a reflux rate of 7. 5 mL/min, a solid-liquid ratio of 1∶8 g/mL, and an extraction time of 2 h. The extraction process for non-volatile components used ethanol with a volume fraction of 65%, solid-liquid ratio of 1∶15 g/mL, extraction time of 50 min, and 3 extraction cycles. The optimal formulation and preparation process for Sugemule-3 Granules were screened, with an average yield of 95. 50%. The extraction process is simple and efficient, and the granule preparation process is feasible, providing a foundation for the development of Sugemule-3 and a scientific experimental basis for its quality control.