| 1,273 | 0 | 37 |
| 下载次数 | 被引频次 | 阅读次数 |
炎症性肠病（inflammatory bowel disease, IBD）是一种临床上比较常见的功能性胃肠疾病.目前关于IBD发病机制的研究主要集中于遗传因素、社会心理因素、内脏高敏感、脑肠轴紊乱、肠道微生态失衡和肠粘膜免疫紊乱等.然而，这些发病机制并不是独立的，随着研究的深入，脑肠轴的异常调节逐渐为人们所重视.本文着重探讨了肠道菌群失调与IBD脑肠轴调节紊乱相关性，为IBD脑肠轴与肠道菌群功能失调的相关发病机制提供有力证据.
Abstract：Inflammatory bowel disease(IBD) is a prevalent functional gastrointestinal disorder in clinical settings.Current research on the pathogenesis of IBD mainly focuses on genetic susceptibility, psychosocial stress, visceral hypersensitivity, dysregulation of the brain-gut axis, dysbiosis of the gut microbiota, and abnormalities in the intestinal mucosal immune system. However, these pathogenic mechanisms are not discrete entities. As research advances, the aberrant regulation of the brain-gut axis is increasingly recognized. This article delves into the correlation between gut microbiota dysbiosis and dysregulation of the brain-gut axis in IBD, offering compelling evidence for the interconnected pathogenic mechanisms involving the brain-gut axis and gut microbiota dysfunction in IBD.
[1]何琼，李建栋.炎症性肠病流行病学研究进展[J].实用医学杂志，2019, 35(18):2962-2966.
[2]李学锋，彭霞，周明欢.我国炎症性肠病流行病学研究进展[J].现代消化及介入诊疗，2020, 25(9):1265-1267.
[3]邹玉凤，牟柏余，陈靖，等.基于脑-肠轴学说探讨中医学防治阿尔茨海默病的理论基础[J].山西中医药大学学报，2024,25(1):100-103.
[4]何其洋，陈敏，龙文玲.基于脑肠轴学说探讨溃疡性结肠炎中医情志发病机制[J].世界最新医学信息文摘，2019,19(82):112-113.
[5]蒋蓝萍.压力应激响应的脑肠轴调控机制[D].深圳：中国科学院大学（中国科学院深圳先进技术研究院），2021.
[6]厉越，韩昌鹏，高凌卉.炎症性肠病和脑-肠轴的相互作用机制研究进展[J].结直肠肛门外科，2020, 26(3):388-392.
[7]熊林林，舒青龙，唐芳瑞，等.基于“脑肠轴”的中医药微生态研究进展[J].时珍国医国药，2021, 32(6):1438-1443.
[8]刘保光，董颖，谢苗，等.基于脑-肠-微生物轴探讨肠道菌群对抑郁症的影响[J].中华中医药杂志，2021, 36(10):6027-6029.
[9]徐玉洁，高娟，王井辉，等.基于脑肠轴探究缺血性脑卒中与肠道菌群免疫的研究进展[J].医学研究与教育，2024,41(1):9-17.
[10]MISIAK B，?ONIEWSKI I, MARLICZ W, et al. The HPA axis dysregulation in severe mental illness:can we shift the blame to gut microbiota?[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 102:109951.
[11]KAELBERER M M, BUCHANAN K L, KLEIN M E, et al. A gut-brain neural circuit for nutrient sensory transduction[J].Science, 2018, 361(6408):eaat5236.
[12]BRAVO J A, FORSYTHE P, CHEW M V, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve[J]. Proceedings of the National Academy of Sciences, 2011,108(38):16050-16055.
[13]BERCIK P, PARK A, SINCLAIR D, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication[J]. Neurogastroenterology&Motility, 2011, 23(12):1132-1139.
[14]WANG S, ISHIMA T, ZHANG J, et al. Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression-and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve[J]. Journal of Neuroinflammation, 2020, 17:1-12.
[15]ZOU Q, HAN S, LIANG J, et al. Alleviating effect of vagus nerve cutting in Salmonella-induced gut infections and anxietylike behavior via enhancing microbiota-derived GABA[J]. Brain, Behavior, and Immunity, 2024, 119:607-620.
[16]BONAZ B, SINNIGER V, PELLISSIER S. Vagus nerve stimulation:a new promising therapeutic tool in inflammatory bowel disease[J]. Journal of Internal Medicine, 2017, 282(1):46-63.
[17]GHIA J E, BLENNERHASSETT P, KUMAR-ONDIVEERAN H, et al. The vagus nerve:a tonic inhibitory influence associated with inflammatory bowel disease in a murine model[J]. Gastroenterology, 2006, 131(4):1122-1130.
[18]ZHANG Z, ZHANG Y, LI J, et al. The neuroprotective effect of tea polyphenols on the regulation of intestinal flora[J].Molecules, 2021, 26(12):3692.
[19]CHEN M, RUAN G, CHEN L, et al. Neurotransmitter and intestinal interactions:focus on the microbiota-gut-brain axis in irritable bowel syndrome[J]. Frontiers in Endocrinology, 2022, 13:817100.
[20]张童，卢慧敏，程婷，等.两歧双歧杆菌B1通过提高乙酸水平调节宿主胃肠调节递质水平及抗氧化能力缓解便秘[J].食品与发酵工业，2025, 51(2):110-117.
[21]HUANG F, WU X. Brain neurotransmitter modulation by gut microbiota in anxiety and depression[J]. Frontiers in Cell and Developmental Biology, 2021, 9:649103.
[22]YONG S J, TONG T, CHEW J, et al. Antidepressive mechanisms of probiotics and their therapeutic potential[J]. Frontiers in Neuroscience, 2020, 13:1361.
[23]GANCI M, SULEYMAN E, BUTT H, et al. The role of the brain-gut-microbiota axis in psychology:the importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders[J]. Brain and Behavior,2019, 9(11):e01408.
[24]STRANDWITZ P, KIM K H, TEREKHOVA D, et al. GABA-modulating bacteria of the human gut microbiota[J]. Nature Microbiology, 2019, 4(3):396-403.
[25]YUNES R, POLUEKTOVA E, VASILEVA E, et al. A multi-strain potential probiotic formulation of GABA-producing Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 with antidepressant effects[J]. Probiotics and Antimicrobial Proteins, 2020, 12:973-979.
[26]BEATA S, MICHA?T, MATEUSZ O, et al. Norepinephrine affects the interaction of adherent-invasive Escherichia coli with intestinal epithelial cells[J]. Virulence, 2021, 12(1):630-637.
[27]刘晨喆，朱进霞.消化道多巴胺的来源、代谢和功能[J].生理学报，2020, 72(3):336-346.
[28]丰丙程. HPA轴过度激活在溃疡性结肠炎中的作用及机制研究[D].济南：山东大学，2022.
[29]余蕾，武文志，张云桥，等. HPA轴在抑郁症中的研究概述[J].昆明医科大学学报，2023, 44(2):166-171.
[30]HEYM N, HEASMAN B, HUNTER K, et al. The role of microbiota and inflammation in self-judgement and empathy:implications for understanding the brain-gut-microbiome axis in depression[J]. Psychopharmacology, 2019, 236:1459-1470.
[31]VANUYTSEL T, VAN WANROOY S, VANHEEL H, et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism[J]. Gut, 2014, 63(8):1293-1299.
[32]SONG J, MA W, GU X, et al. Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone[J]. Journal of Translational Medicine, 2019, 17:1-12.
[33]EUTAMENE H, LAMINE F, CHABO C, et al. Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats[J]. The Journal of Nutrition, 2007, 137(8):1901-1907.
[34]FENG Q, CHEN W D, WANG Y D. Gut microbiota:an integral moderator in health and disease[J]. Frontiers in Microbiology, 2018, 9:151.
[35]JIANG Q, WEI D, HE X, et al. Phillyrin prevents neuroinflammation-induced blood-brain barrier damage following traumatic brain injury via altering microglial polarization[J]. Frontiers in Pharmacology, 2021, 12:719823.
[36]MAN S M. Inflammasomes in the gastrointestinal tract:infection, cancer and gut microbiota homeostasis[J]. Nature Reviews Gastroenterology&Hepatology, 2018, 15(12):721-737.
[37]ZHAN X, LI Q, XU G, et al. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors[J].Frontiers in Immunology, 2023, 13:1109938
[38]WONG M L, INSERRA A, LEWIS M, et al. Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition[J]. Molecular Psychiatry, 2016, 21(6):797-805.
[39]ALCOCER-GóMEZ E, DE MIGUEL M, CASAS-BARQUERO N, et al. NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder[J]. Brain Behavior and Immunity, 2014, 36:1111-1117.
[40]LOWE P P, GYONGYOSI B, SATISHCHANDRAN A, et al. Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression[J]. Journal of Neuroinflammation, 2018, 15:1-12.
[41]朱锡群，易伟.微生物群—脑—肠轴和中枢神经系统研究进展[J].疑难病杂志，2018, 17(7):748-752.
[42]WANG H, HE Y, SUN Z, et al. Microglia in depression:an overview of microglia in the pathogenesis and treatment of depression[J]. Journal of Neuroinflammation, 2022, 19(1):132.
[43]LI H J, LI D Q, ZHANG Y L, et al. Modulation of gut microbiota alleviates cerebral ischemia/reperfusion injury in rats by inhibiting M1 polarization of microglia[J]. Frontiers in Pharmacology, 2023, 14:1123387.
[44]CHEN C, LIAO J, XIA Y, et al. Gut microbiota regulate Alzheimer′s disease pathologies and cognitive disorders via PUFAassociated neuroinflammation[J]. Gut, 2022, 71(11):2233-2352.
[45]HAN Y, ZHAO T, CHENG X, et al. Cortical inflammation is increased in a DSS-induced colitis mouse model[J].Neuroscience Bulletin, 2018, 34:1058-1066.
[46]MOSSAD O, ERNY D. The microbiota-microglia axis in central nervous system disorders[J]. Brain Pathology, 2020,30(6):1159-1177.
[47]COOK J, PRINZ M. Regulation of microglial physiology by the microbiota[J]. Gut Microbes, 2022, 14(1):2125739.
[48]HE H, HE H, MO L, et al. Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice[J]. Brain Behavior and Immunity, 2024, 115:280-294.
[49]ZHAO Y F, WEI D N, TANG Y. Gut microbiota regulate astrocytic functions in the brain:possible therapeutic consequences[J]. Current Neuropharmacology, 2021, 19(8):1354.
[50]LV W J, WU X L, CHEN W Q, et al. The gut microbiome modulates the changes in liver metabolism and in inflammatory processes in the brain of chronic unpredictable mild stress rats[J]. Oxidative Medicine and Cellular Longevity, 2019,2019(1):7902874.
[51]HE X F, LI L L, XIAN W B, et al. Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain[J]. Journal of Neuroinflammation, 2021, 18:1-17.
[52]SHEN X Y, GAO Z K, HAN Y, et al. Activation and role of astrocytes in ischemic stroke[J]. Frontiers in Cellular Neuroscience, 2021, 15:755955.
[53]VAL-LAILLET D, GUERIN S, COQUERY N, et al. Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs[J]. FASEB Journal, 2018, 32(4):2160-2171.
[54]LIU J, FANG Y, CUI L, et al. Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis[J]. Biomedicine&Pharmacotherapy, 2022, 149:112861.
[55]DUAN C, HUANG L, ZHANG C, et al. Gut commensal-derived butyrate reverses obesity-induced social deficits and anxiety-like behaviors via regulation of microglial homeostasis[J]. European Journal of Pharmacology, 2021, 908:174338.
[56]BARICHELLO T, GENEROSO J S, SIM?ES L R, et al. Sodium butyrate prevents memory impairment by re-establishing BDNF and GDNF expression in experimental pneumococcal meningitis[J]. Molecular Nneurobiology, 2015, 52:734-740.
[57]DURING M J, CAO L, ZUZGA D S, et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection[J].Nature Medicine, 2003, 9(9):1173-1179.
[58]MCCLEAN P L, PARTHSARATHY V, FAIVRE E, et al. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer′s disease[J]. Journal of Neuroscience, 2011, 31(17):6587-6594.
[59]CHEN G, RAN X, LI B, et al. Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBSinduced inflammatory bowel disease mice model[J]. EBio Medicine, 2018, 30:317-325.
[60]SMITH P M, HOWITT M R, PANIKOV N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis[J]. Science, 2013, 341(6145):569-573.
[61]HAYASHI H, SHIBATA K, SAKAMOTO M, et al. Prevotella copri sp. nov. and Prevotella stercorea sp. nov., isolated from human faeces[J]. International Journal of Systematic and Evolutionary Microbiology, 2007, 57(5):94194-94196.
[62]LOUIS P, HOLD G L, FLINT H J. The gut microbiota, bacterial metabolites and colorectal cancer[J]. Nature Reviews Microbiology, 2014, 12(10):661-672.
[63]FLINT H J, DUNCAN S H, SCOTT K P, et al. Links between diet, gut microbiota composition and gut metabolism[J].Proceedings of the Nutrition Society, 2015, 74(1):13-22.
[64]REICHARDT N, DUNCAN S H, YOUNG P, et al. Phylogenetic distribution of three pathways for propionate production within the human gut microbiota[J]. The ISME Journal, 2014, 8(6):1323-1335.
[65]SCHWIERTZ A, LEHMANN U, JACOBASCH G, et al. Influence of resistant starch on the SCFA production and cell counts of butyrate-producing Eubacterium spp. in the human intestine[J]. Journal of Applied Microbiology, 2002, 93(1):157-162.
[66]VAN DEN ABBEELE P, BELZER C, GOOSSENS M, et al. Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model[J]. The ISME Journal, 2013, 7(5):949-961.
[67]CIPRIANI S, MENCARELLI A, CHINI M G, et al. The bile acid receptor GPBAR-1(TGR5)modulates integrity of intestinal barrier and immune response to experimental colitis[J]. PLOS One, 2011, 6(10):e25637.
[68]SARATHY J, DETLOFF S J, AO M, et al. The Yin and Yang of bile acid action on tight junctions in a model colonic epithelium[J]. Physiological Reports, 2017, 5(10):e13294.
[69]GOLUBEVA A V, JOYCE S A, MOLONEY G, et al. Microbiota-related changes in bile acid&tryptophan metabolism are associated with gastrointestinal dysfunction in a mouse model of autism[J]. EBio Medicine, 2017, 24:166-178.
[70]AHMED H, LEYROLLE Q, KOISTINEN V, et al. Microbiota-derived metabolites as drivers of gut-brain communication[J].Gut Microbes, 2022, 14(1):2102878.
[71]ANSARI F, NESHAT M, POURJAFAR H, et al. The role of probiotics and prebiotics in modulating of the gut-brain axis[J].Frontiers in Nutrition, 2023, 10:1173660.
[72]赵月月，张丽，杨亚新，等.“互联网+”时代背景下炎症性肠病患者的心理问题及干预研究述评[J].世界华人消化杂志，2021, 29(12):628-632.
基本信息:
DOI：
中图分类号:R574
引用信息:
[1]杨灿娇,王梅,杨恒俐等.肠道菌群介导的脑肠轴通路调控炎症性肠病[J].云南民族大学学报(自然科学版),2025,34(03):284-293.
基金信息:
国家自然科学基金（81960777）; 云南省应用基础研究计划项目中医联合专项重点项目（202101AZ070001-326）; 云南省科学技术厅中医联合面上项目（202001AZ070001-029）